Using Genomic and Transcriptome Analyses to Identify the Role of the Oxidative Stress Pathway in Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 7

A predication model of KIRC using OS-related genes. (a) The expression of OS-related genes in patients with KIRC. In the color bar on the right side, red represents upregulation and blue represents downregulation. N (green) represents the normal sample; T (red) represents the tumor sample (, , and ). (b) Hazard ratio analysis with 95% confidence intervals and values for the OS-related genes. (c) The scatter diagram shows the correlation of SOD2 and other genes, including CYBB, MGST1, TXNRD1, UGT1A6, MAPK14, MAOA, FOS, CAT, MAPK10, SOD3, TXN2, and TXNRD2. (d) Coexpression analysis of OS-related genes in KIRC. (e, f) The LASSO coefficient profiles of OS-related genes in KIRC. Nine genes were selected using the LASSO Cox regression analysis. (g) The survival curve obtained using this model. Red and blue correspond, respectively, to the high-risk group and the low-risk group. (h, k) ROC curve represents data on 3, 5, 7, and 10 years. AUC of the curve is marked at the head (3 years: 0.696; 5 years: 0.734; 7 years: 0.702; and 10 years: 0.729). (l) Heatmap shows the correlation of the nine selected genes and the clinicopathological characteristics in two groups. The color bar represents the expression of genes; red represents upregulation and blue represents downregulation.

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