Using Genomic and Transcriptome Analyses to Identify the Role of the Oxidative Stress Pathway in Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 8

(a) Sankey diagrams used to summarize the data on the nine selected genes, including their expression and prognosis. (b–d) The association between OS-related genes and KIRC was confirmed at the protein level. The boxplot shows the SOD2 protein levels in normal tissues and primary tumor tissues. Immunohistochemical images obtained from the HPA website. (e) The curve shows the result of the gene enrichment score derived from the REACTOME database. (f) Forest plot of univariate Cox analysis. (g) Forest plot of multivariate Cox analysis. (h) Nomogram of the prediction model. The total score is calculated using ABC, from which 5-, 7-, and 10-year survival rates can be obtained. (i) The curve shows the enrichment of the different gene datasets in different physiological functions, including dystroglycan binding, immunoglobulin complex, immunoglobulin complex (circulating), immunoglobulin receptor binding, and phagocytosis, derived from the GO database. (j) The curve shows the result of gene enrichment in endocrine resistance, endocytosis, FoxO signaling pathway, lysosome, and oxidative phosphorylation derived from the KEGG database.

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