Xinkeshu Improves Endothelial Function and Augments Reendothelialization Capacity in Coronary Artery Disease with Anxiety/Depression

Figure 5

XKS regulates CXCR7/p38/cleaved casepase-3 pathway and inhibits apoptosis of EPCs from CAD patients with anxiety/depression. (a) The quantification analyses of CXCR7 mRNA (vs. the vehicle group, ). (b) The protein bands of CXCR7 and GAPDH and the mean value of CXCR7/GAPDH ratio ( and vs. the vehicle group, ). (c) The protein bands of CXCR7 and GAPDH after transfecting with siRNA-CXCR7 and the mean value of CXCR7/GAPDH ratio (vs. the non-XKS group, ). (d) The protein bands of p-p38, p38, and GAPDH and the mean value of p-p38/p38 ratio (vs. the blank group, ). (e) The protein bands of cleaved casepase-3 and GAPDH and the mean value of cleaved casepase-3/GAPDH ratio (vs. the non-XKS group, ). (f) The quantification analyses of apoptosis cells rate measured by flow cytometry (vs. the XKS group; per group).

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