Xinkeshu Improves Endothelial Function and Augments Reendothelialization Capacity in Coronary Artery Disease with Anxiety/Depression

Figure 6

XKS-mediated CXCR7 signaling improves in vitro functions and in vivo endothelial repair capacity of EPCs. (a) The representative photographs of migration and adhesion function, (b) the mean value of migrated cell numbers (vs. the non-XKS group, ), and (c) the mean value of adhering cell numbers (vs. the non-XKS group, ) of EPCs. (d) The quantification analyses and (e) representative photographs of reendothelialization areas (white) of the injured carotid arteries in nude mice 3 days after carotid denudation surgery plus intravenous injection of EPCs ( cells) with or without XKS (vs. the non-XKS group, ). (f) The pathological changes of endothelium from carotid arteries in hematoxylin-eosin (HE) and immunohistochemistry (IHC) staining of CD31 (magnification: 400).

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