Inhibition of α-Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice

Figure 3

Peripheral surgery increased mitochondrial α-syn accumulation and damage. (a) The hippocampus was stained to determine colocalization of α-syn (red) and COXIV (an inner mitochondrial membrane (green)). Cell nuclei were stained with DAPI (blue). Arrows point to mitochondrial α-syn; , . (b) Transmission electron microscopy showing mitochondrial morphology in the hippocampus after surgery ( mice per group) and assessment of abnormal cristae ( cells). . Results are presented as (one-way analysis of variance). , control (Con) or anesthesia-alone (Ane) vs. surgery plus anesthesia (Sur).

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