Melatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation Signaling

<div>Schematic representation for the protective role of melatonin against NAM-induced toxicity in oocytes. NNMT: nicotinamide-N-methyltransferase; metNAM: N-methyl-nicotinamide; AHCY: adenosylhomocysteinase; AOX1: aldehyde oxidase; HCY: homocysteine; 2-PY: N-methyl-2-pyridone-5-carboxamide; 4-PY: N-methyl-4-pyridone-5-carboxamide; ROS: reactive oxygen species; NAM: nicotinamide; MT: melatonin.</div>

Oxidative Medicine and Cellular Longevity

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Figure 8

Figure 8: Melatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation Signaling 

Figure 8 | Melatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation Signaling 