Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis

Figure 5

LINC00909 functions as an oncogenic factor to ovarian cancer cells. (a) MTT assay determined cell proliferation of SKOV3 cells. ^# indicates independent targets. . (b, c) Colony formation (b) and soft agar (c) assays revealed the tumor characteristics of each SKOV3 cell line. Cells in (a) were used. ; scale bar, 1 mm. (d) Wound healing assay determined the migration of SKOV3. Cells in (a) were used. Comparisons with day 2 of the scramble group; ^$comparisons with day 3 of the scramble group; scale bar, 200 μm. (e) Transwell assay determined the invasion of SKOV3 and OVCAR4 cells. The cells were the same with (a) and S2C. Scale bar, 50 μm. (f) Western blot showed the protein level of EMT markers in SKOV3 cells. Cells in (a) were used. E-cadherin, epithelial marker; N-cadherin/vimentin, mesenchymal marker.

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