Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo

Figure 8

Schematic model illustrating the autophagy regulative mechanism of GSDMD-mediated pyroptosis. Autophagy inhibition promotes the accumulation of cytoplasmic GSDMD-N and elicits cell membrane perforation (a). Upon autophagy activation, P62 mediates the degradation of GSDMD-N in autolysosome and reduces the cell pyroptosis (b). NLRP3: NLR family PYRIN domain-containing 3; ASC: apoptosis-associated speck-like protein containing a CARD; NLRC4: NLR family CARD domain-containing protein 4; GSDMD: gasdermin D; GSDMD-N: N-terminal of gasdermin D; GSDMD-C: C-terminal of gasdermin D; P62: SQSTM1/sequestosome 1.