Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway

Figure 4

KRL activates the PI3/AKT signaling. (a) HUVECs cells were treated with B[a]P (5 μmol) and/or KRL (5, 10, and 25 μmol) for 24 hours. The findings of western blotting reveal the impacts of KRL on anti-pPI3K and anti-pAKT. The expression’s relative ratios shown in the results of western blotting are presented below each of the results in the form of values that are relative to PI3K and AKT expression. (b) Nrf2, NQO-1, and HO-1 expression was assessed by RT-PCR. Data is represented as the of triplicate values (), and represents major variations as compared to the control. ^# meanwhile signifies noteworthy discrepancies in comparison to the B[a]P alone and KRL with the B[a]P treatment groups.

(a)

(b)