Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation

<div>Mitochondrial dysfunction caused by mROS from Sarm1-KR and IR. (a) Representative FCM pictures of MMP in HeLa cells stained by Rh123 and analyzed by FCM. (b) The changes of Na<sup>+</sup>K<sup>+</sup>-ATPases, Ca<sup>2+</sup>Mg<sup>2+</sup>-ATPase, and mito-respiratory complex I and III activities by biochemical assay after light exposure and IR. (c) WB analysis was performed to determine protein levels of VDAC1 in total- and mito-protein. <i>β</i>-Actin and HSP60 proteins were used for loading control. (d) From top to bottom, the changes of VDAC1/<i>β</i>-actin and VDAC1/HSP60. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation 