Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation

<div>Sarm1-mtKR-induced mtROS participated in the autophagic cell death depending on the Pink1/PARK2 pathway. (a) WB was performed to determine protein levels of Pink1, PARK2, and Tom20 in total- and mito-proteins. GAPDH and HSP60 proteins were used for loading control. (b) The gray ratios of Pink1, PARK2, and Tom20 in total- and mito-proteins. (c) Pink1 and Tom20 mRNAs detected by qRT-PCR. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation 