Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Table 2

Effect of 16-week administration of abacavir and etravirine on macrometric parameters (AB group: group receiving abacavir 60 mg/kg for 16 weeks; ET group: group receiving etravirine 40 mg/kg for 16 weeks). Results presented as median (lower quartile–upper quartile); ^AB group vs. control group, ; ET group vs. control group, .

	Control group	AB group	ET group
Weight of testis [g]	1.736 (1.459-1.895)	1.742 (1.644-1.854)	1.706 (1.570-1.797)
Testicular index [%]	0.790 (0.677-0.876)	0.775 (0.739-0.857)	0.781 (0.679-0.831)
Weight of liver [g]	10.49 (9.96-11.03)	11.13 (10.75-11.93)	11.21 (10.92-12.00)
Hepatic index [%]	2.405 (2.310-2.503)	2.598 (2.500-2.664)	2.680 (2.469-2.788)
Weight of kidney [g]	1.275 (1.147-1.425)	1.311 (1.192-1.398)	1.264 (1.207-1.357)
Renal index [%]	0.578 (0.532-0.618)	0.591 (0.571-0.605)	0.599 (0.537-0.645)
Tibia weight [g]	0.787 (0.753-0.841)	0.827 (0.792-0.840)	0.830 (0.820-0.873)
Tibial index [%]	0.183 (0.174-0.192)	0.183 (0.178-0.197)	0.195 (0.184-0.210)
Tibia length [mm]	41.73 (41.38-42.45)	41.94 (41.74-42.38)	41.82 (41.27-42.52)
Mid-tibial diameter [mm]	2.47 (2.43-2.52)	2.54 (2.41-2.67)	2.61 (2.55-2.66)
Femur weight [g]	1.151 (1.131-1.173)	1.151 (1.095-1.178)	1.150 (1.096-1.189)
Femoral index [%]	0.265 (0.253-0.271)	0.255 (0.247-0.273)	0.271 (0.255-0.281)
Femur length [mm]	38.24 (37.65-38.62)	37.88 (37.72-38.65)	37.64 (37.34-38.18)
Mid-femoral diameter [mm]	3.485 (3.36-3.53)	3.505 (3.435-3.630)	3.59 (3.51-3.68)