Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Table 3

Effect of 16-week administration of abacavir and etravirine on levels of reproductive hormones in serum and in testicular homogenates (AB group: group receiving abacavir 60 mg/kg for 16 weeks; ET group: group receiving etravirine 40 mg/kg for 16 weeks; LH: luteinising hormone; FSH: follicle-stimulating hormone; SHBG: sex hormone-binding globulin; TSH: thyroid-stimulating hormone. Results presented as median (lower quartile–upper quartile); ^AB group vs. control group, ; ET group vs. control group, ).

		Control group	AB group	ET group
Week 8 serum	LH [mIU/ml]	4.93 (4.39-5.64)	4.60 (3.52-5.38)	3.99 (3.83-4.48)
	FSH [mIU/ml]	2.09 (1.95-2.31)	2.05 (1.83-2.23)	2.25 (2.13-2.36)
	Testosterone [ng/l]	104.1 (93.5-109.0)	98.1 (88.4-104.6)	105.7 (94.0-112.7)
	Estradiol [ng/l]	33.6 (32.6-36.3)	33.8 (32.2-36.2)	33.3 (31.4-35.6)
	SHBG [ng/ml]	1.52 (1.26-1.67)	1.26 (1.09-1.67)	1.31 (1.09-1.52)
Week 16 serum	LH [mIU/ml]	4.0 (3.54-4.42)	3.30 (3.13-3.40)	4.12 (3.33-4.25)
	FSH [mIU/ml]	1.94 (1.73-2.08)	1.89 (1.62-2.15)	1.92 (1.51-2.22)
	Testosterone [ng/l]	99.8 (91.0-113.3)	97.6 (88.7-107.3)	100.3 (91.7-104.9)
	Estradiol [ng/l]	31.5 (28.0-35.8)	32.0 (29.5-33.1)	33.0 (30.7-34.6)
	Inhibin B [ng/l]	27.2 (17.7-28.8)	26.8 (22.2-33.7)	26.3 (21.7-29.2)
	SHBG [ng/ml]	1.35 (1.26-1.61)	1.39 (1.22-1.64)	1.24 (1.13-1.51)
	Prolactin [ng/ml]	8.18 (5.82-9.23)	7.62 (6.13-8.07)	6.77 (6.21-8.41)
	TSH [mIU/ml]	1.68 (1.42-2.06)	1.96 (1.56-2.05)	1.76 (1.57-1.95)
Week 16 testicular homogenates	Testosterone [ng/l]	71.1 (68.8-74.1)	76.6 (72.4-84.1)	82.9 (72.7-94.1)
	Estradiol [ng/l]	173.9 (169.0-185.0)	194.4 (164.1-208.7)	192.6 (172.0-205.4)
	Inhibin B [ng/l]	54.6 (43.5-57.1)	59.5 (50.7-64.8)	52.7 (47.0-58.4)