Oxidative Medicine and Cellular Longevity

Research Article

Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Table 5

Effect of abacavir and etravirine administration on serum parameters after 4 and 16 weeks (AB group: group receiving abacavir 60 mg/kg for 16 weeks; ET group: group receiving etravirine 40 mg/kg for 16 weeks; PINP: N-terminal propeptide of type I procollagen; TRACP: tartrate-resistant acid phosphatase from 5b; DKK1: Dickkopf-related protein 1; OPG: osteoprotegerin; 25-OH-D: 25-hydroxyvitamin D. Results presented as median (lower quartile-upper quartile); ^AB group vs. control group, ; ET group vs. control group, ).


		Control group	AB group	ET group

Week 4	PINP [ng/ml]	14.6 (10.9-18.9)	18.1 (11.9-23.0)	12.4 (7.0-17.6)
	TRACP [U/l]	2.4 (1.8-2.8)	2.2 (2.0-2.7)	2.6 (1.9-2.9)
	Sclerostin [pg/ml]	1037.7 (983.6-1336.8)	1101.0 (1008.6-1193.0)	1110.6 (982.8-1182.1)
	DKK1 [ng/ml]	3.9 (3.5-7.7)	5.3 (3.2-6.7)	5.2 (4.4-7.8)
	OPG [pg/ml]	165.5 (154.0-169.5)	150.1 (132.9-163.4)	123.9 (98.7-167.4)
	1,25-dihydroxyvitamin D₃ [nmol/l]	7.9 (6.0-8.2)	6.9 (6.5-7.6)

Week 16	PINP [ng/ml]	0.8 (0.5-1.1)	0.7 (0.6-0.8)	0.7 (0.6-0.9)
	TRACP [U/l]	1.3 (0.9-1.5)	1.1 (1.0-1.3)	1.1 (1.0-1.3)
	Sclerostin [pg/ml]	836.3 (726.6-1047.0)	830.7 (559.4-884.6)	859.7 (774.5-1010.1)
	DKK1 [ng/ml]	3.0 (1.9-5.3)	5.4 (3.2-12.5)^	2.7 (2.0-5.5)
	OPG [pg/ml]	79.7 (70.0-96.1)	86.4 (58.9-113.9)	102.9 (73.4-124.5)
	25-OH-D [nmol/l]	2.0 (1.7-2.1)	2.0 (1.8-2.2)	2.0 (1.8-2.2)
	1,25-dihydroxyvitamin D₃ [nmol/l]	6.3 (5.8-9.3)	6.8 (4.5-7.3)	6.6 (5.2-8.1)
	Parathormone [pg/ml]	42.0 (33.7-53.3)	47.0 (41.9-51.5)	49.2 (45.6-52.1)
	Total calcium [mg/dl]	9.3 (9.0-9.6)	9.3 (8.9-9.5)	9.1 (9.0-9.3)
	Inorganic phosphorus [mg/dl]	6.0 (5.0-7.4)	6.2 (5.7-7.6)	5.2 (5.0-6.6)
	Aspartate aminotransferase [U/l]	0.33 (0.25-0.50)	0.51 (0.48-0.75)^	0.39 (0.34-0.55)
	Creatinine [mg/dl]	0.33 (0.29-0.38)	0.33 (0.28-0.35)	0.29 (0.26-0.33)