Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Table 7

Effect of 16-week administration of abacavir and etravirine on the tibia assessed using histopathological examination (AB group: group receiving abacavir 60 mg/kg for 16 weeks; ET group: group receiving etravirine 40 mg/kg for 16 weeks; BV/TV: bone volume/tissue volume; BS/TV: bone surface/tissue volume; BS/BV: bone surface/bone volume ratio; Tb.Th: trabecular thickness. Results presented as median (lower quartile–upper quartile); ^AB group vs. control group, ).

	Control group	AB group	ET group
BV/TV [%]	18.3 (12.6-21.6)	24.6 (23.3-26.4)^	17.2 (14.4-19.8)
BS/TV [mm^2/mm^3]	7.61 (7.17-9.49)	9.93 (9.68-10.7)^	8.41 (7.09-9.54)
BS/BV [mm^2/mm^3]	47.5 (36.2-53.4)	40.8 (35.7-46.3)	49.1 (41.4-52.6)
Tb.Th [mm]	0.042 (0.037-0.055)	0.049 (0.043-0.0056)	0.041 (0.038-0.048)