Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Table 8

Effect of 16-week administration of abacavir and etravirine on the cancellous and cortical bone of the tibia and femur assessed using micro-X-ray computed tomography (AB group: group receiving abacavir 60 mg/kg for 16 weeks; ET group: group receiving etravirine 40 mg/kg for 16 weeks; BV/TV: bone volume fraction; BS/TV: bone surface density; BS/BV: specific bone surface; Tb.Th: trabecular thickness; Tb.N: trabecular number; Tb.Sp: trabecular separation; SMI: structure model index; Conn.D: connectivity density; Po.tot: total porosity; DA: degree of anisotropy; Ct.Th: average cortical thickness; Tt.Ar: total cross-sectional area inside the periosteal envelope; Ct.Ar: cortical bone area; Ct.Ar/Tt.Ar: cortical area fraction. Results presented as median (lower quartile–upper quartile); ^AB group vs. control group, ).

			Control group	AB group	ET group
Tibia	Cancellous bone	BV/TV [%]	13.2 (11.6-14.3)	14.7 (12.7-17.9)^	13.8 (12.7-15.9)
		BS/TV [mm^2/mm^3]	6.1 (4.6-6.6)	6.7 (5.6-7.7)	6.5 (5.8-6.8)
		BS/BV [mm^2/mm^3]	45.0 (43.0-47.9)	43.8 (42.7-46.4)	44.9 (42.6-47.2)
		Tb.Th [mm]	0.083 (0.080-0.087)	0.084 (0.081-0.086)	0.083 (0.080-0.086)
		Tb.N [1/mm]	1.64 (1.23-1.74)	1.80 (1.49-2.11)^	1.75 (1.54-1.87)
		Tb.Sp [mm]	0.52 (0.49-0.77)	0.44 (0.38-0.58)	0.44 (0.41-0.56)
		SMI [-]	2.15 (2.04-2.23)	2.07 (1.95-2.16)	2.01 (1.95-2.22)
		Conn.D [1/mm^3]	41.4 (27.4-45.5)	46.3 (35.5-59.8)^	44.5 (38.7-48.2)
		Po.tot [%]	86.8 (85.6-88.3)	85.2 (82.1-87.3)^	86.2 (84.1-87.3)
		DA [-]	1.70 (1.54-1.76)	1.65 (1.62-1.75)	1.68 (1.59-1.76)
Tibia	Cortical bone	Ct.Th [mm]	0.62 (0.61-0.65)	0.63 (0.60-0.64)	0.63 (0.62-0.65)
		Tt.Ar [mm^2]	48.3 (47.8-49.1)	50.7 (48.7-52.4)	51.2 (49.2-53.1)
		Ct.Ar [mm^2]	63.2 (61.3-65.8)	66.2 (62.6-69.4)	64.4 (63.0-69.6)
		Ct.Ar/tt.Ar [%]	1.29 (1.26-1.31)	1.29 (1.26-1.33)	1.28 (1.25-1.36)
Femur	Cancellous bone	BV/TV [%]	18.3 (15.7-19.0)	18.2 (16.4-20.4)	18.7 (16.7-20.3)
		BS/TV [mm^2/mm^3]	7.85 (6.14-8.12)	7.37 (7.11-8.73)	7.83 (7.48-8.46)
		BS/BV [mm^2/mm^3]	42.5 (41.0-44.1)	42.7 (41.8-43.3)	42.9 (41.7-44.8)
		Tb.Th [mm]	0.086 (0.084-0.089)	0.085 (0.083-0.088)	0.085 (0.083-0.087)
		Tb.N [1/mm]	2.16 (1.71-2.22)	2.04 (1.93-2.40)	2.16 (2.02-2.31)
		Tb.Sp [mm]	0.53 (0.49-0.75)	0.56 (0.42-0.68)	0.52 (0.45-0.61)
		SMI [-]	1.76 (1.72-1.81)	1.71 (1.61-1.77)	1.69 (1.65-1.84)
		Conn.D [1/mm^3]	75.4 (52.9-80.6)	73.5 (69.6-86.9)	79.5 (71.2-84.3)
		Po.tot [%]	81.7 (81.0-84.3)	81.8 (79.5-83.6)	81.3 (79.7-83.3)
		DA [-]	1.23 (1.22-1.26)	1.21 (1.17-1.25)	1.24 (1.21-1.25)
Femur	Cortical bone	Ct.Th [mm]	0.74 (0.73-0.76)	0.73 (0.70-0.75)	0.72 (0.71-0.74)
		Tt.Ar [mm^2]	47.5 (45.2-48.7)	47.9 (47.0-49.4)	48.6 (47.0-51.0)
		Ct.Ar [mm^2]	56.8 (55.3-57.6)	57.5 (55.8-62.2)	60.0 (56.0-63.4)
		Ct.Ar/tt.Ar [%]	1.20 (1.17-1.22)	1.21 (1.18-1.26)	1.21 (1.18-1.25)