Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

Figure 1

Comparison of outcome in control and THD groups. (a) Reduction of NIHSS in the two treatment groups. NIHSS was reduced more in the THD group than in the control group (Wilcoxon rank sum test, , (control) vs. (THD)). (b) Reduction of mRS in the two treatment groups. mRS was reduced more in the THD group than in the control group (Wilcoxon rank sum test, , (control) vs. (THD)). (c) Reduction of fire-heat score in the two treatment groups. Fire-heat score was reduced more in the THD group than in the control group (Wilcoxon rank sum test, , (control) vs. (THD)). (d) Increment of BI in the two treatment groups. BI was improved more in the THD group than in the control group (Wilcoxon rank sum test, , (control) vs. (THD)). (e) IED to the health group for AIS samples after treatment (family level). Gut microbiota of AIS patients in the THD group became closer to health samples than those in the control group on family level (Wilcoxon rank sum test, , (control) vs. (THD)). (f) IED to the health group for AIS samples after treatment (genus level). Gut microbiota of AIS patients in the THD group became closer to health samples than those in the control group on genus level (Wilcoxon rank sum test, , (control) vs. (THD)). (g) Increment of alpha diversity (Shannon) of AIS samples. In THD group, the Shannon indices of AIS samples were increased, while they were decreased in the control group (Wilcoxon rank sum test, , (control) vs. (THD)). (h) Increment of alpha diversity (Chao1) of AIS samples. In THD group, the Chao1 indices of AIS samples were increased, while they were decreased in the control group (Wilcoxon rank sum test, , (control) vs. (THD)). Shannon diversity +: the increment of Shannon diversity; Chao1 +: the increment of Chao1. , , and .

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