Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

Figure 10

Hypothesis of the therapeutic mechanism of THD on AIS. The gut microbiota can be disrupted with the innervation of the dysfunctional nerve system in AIS patients. The disordered gut microbiota will produce LPS and the precursor of TMAO aberrantly. The sterile inflammation and platelet aggregation in the nerve system and vascular system, induced by LPS and TMAO, will aggravate AIS further. TCM will mediate the gut bacteria and subsequently reduce the levels of LPS and TMAO and then inhibit the aggravation of AIS. Blue solid line: included in our analysis results; blue dotted line: need to be verified further.