Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

Figure 3

Bacterial co-occurrence network pre and post treatment in control group. (a) Co-occurrence network of genera before treatment in control group. The network was dominated by a chain of hub genera, including Clostridium, Citrobacter, Faecalibacterium, Eggerthella, Ruminococcus, Blautia, Prevotella, Alloscardovia, Roseburia, Coprococcus, etc. Bacteroides, an LPS-producing genus, competed with two genera and was complementary to one genus. (b) Co-occurrence network of genera after treatment in control group. In control group, the co-occurrence network was simplified after treatment, characterized by the reduced connections and complexity compared to the network before treatment. The chain appearing before treatment disappeared after treatment and a closed loop predominant by SCFA-producing genera occurred. Bacteroides became to collaborate with other genera. Red line: negative correlation; Blue line: positive correlation; the color of nodes stands for the phylum of the genus; the size of a node stands for the average abundance of the genus; the ellipses with different lines represent different clusters.

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