Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

Figure 8

Significantly different KEGG pathways and comparisons of bacterial contribution on “Lipopolysaccharide biosynthesis proteins” KEGG BRITE, “Lipopolysaccharide biosynthesis” KEGG PATHWAY, and mttB gene between pretreatment and posttreatment samples in the THD group. (a) Significantly different KEGG pathways between pre- and posttreatment samples in the THD group using Linear discriminant analysis effect size (LEfSe) analysis (>2 log (LDA score)). (b) Relative bacterial contribution on “Lipopolysaccharide biosynthesis proteins” KEGG BRITE pre and post treatment in the THD group. “Lipopolysaccharide biosynthesis proteins” KEGG BRITE enriched before treatment in the THD group. Bacteroides and Meganomas contributed less on “Lipopolysaccharide biosynthesis proteins” KEGG BRITE after treatment. (c) Relative bacterial contribution on “Lipopolysaccharide biosynthesis” KEGG PATHWAY before and after treatment in the THD group. “Lipopolysaccharide biosynthesis” KEGG PATHWAY enriched before treatment. Bacteroides, Clostridium, Prevotella, and Dialister contributed less on “Lipopolysaccharide biosynthesis” KEGG PATHWAY after treatment. (d) Relative bacterial contribution on mttB gene before and after treatment in the THD group. mttB gene enriched after treatment. Blautia and Acetobacterium contributed more after treatment. The top five bacterial donators in each group are shown in detail, and others were aggregated into “Others.” Pre-THD: pretreatment samples in the THD group; Post-THD: posttreatment samples in the THD group.

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