The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway
Table 1
The mutual metabolites in urine of various periods.
Metabolites
Day 7
Day 21
Day 35
Trend
VIP
Trend
VIP
Trend
VIP
Myristic acid
+++
3.461
++
1.509
++
2.133
3,6-Octadienoylglycine
++
2.105
--
1.946
++
1.828
Uracil
++
1.968
/
0.063
+
1.161
Mevalonic acid
+
1.663
/
0.021
/
0.189
3-Hydroxybutyric acid
-
1.078
--
1.501
--
1.943
Pantothenic acid
+
0.824
++
1.409
/
0.528
1-Methyluric acid
-
0.822
/
0.092
++
1.723
Epinephrine
+
0.578
+
0.924
/
0.055
4-Hydroxyproline
/
0.299
+
1.119
+
1.106
Succinic acid semialdehyde
/
0.252
-
0.241
-
0.327
1-Methylhistidine
-
0.213
/
0.004
+
1.148
Note: “-” represents metabolites with a downregulated trend, “+” represents metabolites with an upregulated trend, “--” and “++” represent significant difference from control at , and “---” and “+++” represent significant difference from control at .
