THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma

<div>THAP9-AS1 activated the JAK2/STAT3 signaling pathway by regulating SOCS3. (a) THAP9-AS1 induced p-JAK2 and p-STAT3 (Tyr705) protein upregulation, which could be reversed by SOCS3. (b) p-STAT3 nuclear translocation in the different groups of cells was analyzed by IF assay, and representative images are shown; scale bars: 100 <i>μ</i>m. pcSOCS3: SOCS3 expressing vectors.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4: THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma 

Figure 4 | THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma 