Roles of the Immune/Methylation/Autophagy Landscape on Single-Cell Genotypes and Stroke Risk in Breast Cancer Microenvironment

Figure 9

Clustering analysis of six BCPRS-related genes and cell annotation of TNBC adipocyte subsets. (a) Six-clustering analysis of BCPRS-related genes groups TNBC cells into three clusters; cluster 3 was defined as low BCPRS whereas cluster 2 was defined as the high BCPRS group. (b) Line chart of cell classification percentage in each BCPRS-related cluster. (c) All 3 clusters of adipocytes in TNBC were annotated by CellMarker. (d) Trajectory analysis showed differential distribution of cells (macrophages, adipose-derived stem cells, and fat cells) at different pseudotimes. (e) Distribution of cluster 2 (low BCPRS cluster) and cluster 1 (high BCPRS cluster) in adipocytes. (f, g) Line chart of adipocyte percentage in BCPRS-related clusters 2 and 3 (f); trajectory analysis showed the differential distribution of high/low BCPRS cluster at different pseudotimes (g). (h) Relative level of macrophages in low and high BCPRS groups. Significant differences were observed (). (i) Relative level of miRNAsi in low and high BCPRS groups. Significant differences were observed ().

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