SPP1 Promotes Enzalutamide Resistance and Epithelial-Mesenchymal-Transition Activation in Castration-Resistant Prostate Cancer via PI3K/AKT and ERK1/2 Pathways

<div>The effect of SPP1 knockdown on adhesion and migration of CRPC cells. (a) Matrigel transwell assay in SPP1 depleted and control groups. DU-145 and 22Rv1 adhesion was significantly decreased in SPP1 knockdown cell lines. (b, c) Wound closure assay in SPP1 depleted and control groups. An obvious decrease in the rate of wound closure was showed in the SPP1 siRNA-transfected group. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: SPP1 Promotes Enzalutamide Resistance and Epithelial-Mesenchymal-Transition Activation in Castration-Resistant Prostate Cancer via PI3K/AKT and ERK1/2 Pathways 

Figure 7 | SPP1 Promotes Enzalutamide Resistance and Epithelial-Mesenchymal-Transition Activation in Castration-Resistant Prostate Cancer via PI3K/AKT and ERK1/2 Pathways 