Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury

Figure 1

FMT can rescue the alteration of gut microbiota due to TBI. (a, b) The sequence reads and OTUs among the sham, TBI, TBI+saline, and TBI+FMT groups, at 8 days after injury. (c) Indices of α-diversity measured by Shannon, Ace, Chao, Coverage, and Shannon even in the sham, TBI, TBI+saline, and TBI+FMT groups, at 8 days after injury. (d) PCoA of the gut microbiome composition on OTU level based on the Bray-Curtis distance for FMT in TBI rats (, ). Each point indicates samples from rats of each group, which is indicated by a different color and shape. PC: principal component. (e–g) Bar plot analysis of gut microbiota relative abundance of bacterial phylum, family, and genus in the sham, TBI, TBI+saline, and TBI+FMT groups. Different colors represent different phyla, family, and genus. (h) Significant differences in the abundance of phyla in each group. (i) Significant differences in the abundance of families with high abundance (top 10). (j) Significant differences in the abundance of genus with high abundance (top 15) ( rats in each group). Data are presented as the . , , one-way ANOVA.

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