Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury

Table 2

The significantly differential serum metabolites among the sham, TBI+FMT, and TBI+saline groups.

Metabolites	Rt (s)		VIP (a)	FC (a)	value (a)	VIP (b)	FC (b)	value (b)	VIP (c)	FC (c)	value (c)
1-O-(cis-9-Octadecenyl)-2-O-acetyl-sn-glycero-3-phosphocholine	189.098	550.384	2.461	0.822	0.037	2.890	1.326	0.001	0.891	1.091	0.256
L-Palmitoylcarnitine	174.714	400.341	1.956	0.851	0.106	2.651	1.246	0.014	0.161	1.060	0.500
L-Citrulline	444.719	176.101	1.082	0.680	0.005	1.089	1.435	0.014	0.142	0.976	0.826
1-Palmitoyllysophosphatidylcholine	189.717	538.384	1.891	0.816	0.035	1.800	1.163	0.022	0.741	0.949	0.560
Sphingomyelin (d18 : 1/18 : 0)	139.739	794.603	1.618	1.087	0.340	2.504	1.144	0.024	3.274	1.244	0.005
Sarcosine	317.225	131.080	0.525	1.031	0.850	1.200	0.726	0.024	0.740	0.748	0.108
Glycochenodeoxycholate	215.888	450.318	1.410	3.327	0.003	1.307	0.497	0.037	0.327	1.652	0.126
L-Phenylalanine	282.802	166.084	1.181	1.174	0.022	2.256	0.790	0.040	0.716	0.849	0.267
L-Alanine	373.579	90.054	2.132	0.326	0.056	1.561	0.715	0.043	1.237	0.759	0.099
Dioctyl phthalate	233.342	391.282	0.761	0.680	0.086	1.141	1.879	0.046	0.434	1.277	0.401
1-Stearoyl-sn-glycerol 3-phosphocholine	213.909	524.368	1.262	0.958	0.738	1.506	0.847	0.054	1.293	0.811	0.136
Trimethylamine N-oxide	333.593	76.074	1.953	3.936	0.035	1.477	0.341	0.062	0.436	1.343	0.442
Cortexolone	48.584	347.219	0.416	0.874	0.483	1.064	0.655	0.075	0.934	0.572	0.013
5-Methylcytosine	207.507	126.065	0.251	0.928	0.595	1.090	1.236	0.087	0.930	1.146	0.186

Abbreviations: FC: fold change; : mass-to-charge ratio; Rt: retention time; VIP: variable importance in the projection. VIP (a) or FC (a): TBI+saline versus the sham group; VIP (b) or FC (b): TBI+FMT versus the TBI+saline group; VIP (c) or FC (c): TBI+FMT versus the sham group.