Ionizing Radiation Upregulates Glutamine Metabolism and Induces Cell Death via Accumulation of Reactive Oxygen Species

Figure 1

Ionizing radiation inhibits cell proliferation. MCF-7 and HCT-116 cells were irradiated with X-rays at different doses. At 48 h after irradiation, the morphology of cells became swollen (a). Clonal formation was inhibited by radiation in a dose-dependent manner (b). The expression of c-Myc protein was decreased after irradiation with different doses of X-rays and carbon ions (c). 2 Gy X-ray irradiation reduced the malignancy index of the MCF-7 tumor cells (d). of triplicate assessments, one-way ANOVA with post hoc Dunnett test, , , and (b, c). Student’s unpaired -test, (d).

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