High-Fat Diet-Induced Fatty Liver Is Associated with Immunosuppressive Response during Sepsis in Mice

Figure 1

Mice on high-fat diet have aggravated septic symptoms. (a) Mice fed with normal chow (NC) or high-fat diet (HFD) for 15 weeks. Representative liver sections of hematoxylin and eosin (H&E) staining. (b) Changes in the body weight of mice fed NC () or HFD () for 15 weeks. (c) TG content in liver of mice fed NC () or HFD (). (d) The survival rate of the NC group () and the HFD group () after LPS (10 mg/kg) intraperitoneal injection. (e) Body temperature in mice 12 h after LPS (10 mg/kg) intraperitoneal injection or control treatment. NC (), HFD (), NC+LPS (), and HFD+LPS (). (f) Plasma levels of AST (NC , HFD , NC+LPS , and HFD+LPS ) were measured in NC and HFD groups injected with or without LPS (10 mg/kg). by two-tailed Student’s -test.  μm.

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