[Retracted] ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes

Figure 1

Alcohol-induced liver tumor development. Alcohol induces JNK1 activation to upregulate c-Jun expression through Elk-1. Elk-1 and c-Jun augment TBP and Brf1 expression to enhance Pol III gene transcription, resulting in liver tumor development. Blue P: phosphorylation group.