Roles of Suaeda vermiculata Aqueous-Ethanolic Extract, Its Subsequent Fractions, and the Isolated Compounds in Hepatoprotection against Paracetamol-Induced Toxicity as Compared to Silymarin

Table 1

Effects of S. vermiculata aq.-ethanolic extract, fractions, and isolated compounds on liver functions of the PCM-induced liver toxicity in the experimental mice.

Animal groups	AST IU/L	ALT IU/L	TP g/dL
I. Intact control (no CMC, no extract/no fractions, no PCM)	^C	^B	^A
II. Negative control (vehicle CMC 0.5%)+PCM	^A	^A	^A
III. Silymarin 100 mg/kg+PCM	^B,C	^B	^A
IV. Pheophytin-A 100 mg/kg+PCM	^B,C	^B	^A
V. Isorhamnetin-3-O-rutinoside 100 mg/kg+PCM	^BC	^B	^A
VI. Quercetin 100 mg/kg+PCM	^B,C	^B	^A
VII. Aqueous-ethanolic extract 400 mg/kg+PCM	^B,C	^B	^A
VIII. n-Butanol fraction 400 mg/kg+PCM	^C	^B	^A
IX. Ethyl acetate fraction 400 mg/kg+PCM	^B,C	^B	^A
X. Chloroform fraction 400 mg/kg+PCM	^B,C	^B	^A
X1. n-Hexane fraction 400 mg/kg+PCM	^B	^B	^A

Values denoted are the . AST: aspartate transaminase; ALT: alanine transaminase; TP: total protein; CMC: carboxyl methylcellulose; PCM: paracetamol. not sharing the letters (A–C) in the respective column (AST, ALT, and TP) are significantly different (). Raw data is available in the Supplementary file (Table S1).