Pentoxifylline Attenuates Arsenic Trioxide-Induced Cardiac Oxidative Damage in Mice

Figure 5

Photomicrographs of cardiac tissue in different groups: (a) control group; (b) ATO; (c) PTX (100 mg/kg); (d) (25 mg/kg); (e) (50 mg/kg); (f) (100 mg/kg). The samples were dyed by hematoxylin and eosin. Original magnification of upper row photomicrographs is 400x and lower row photomicrographs 100x. Cardiac tissue samples of the control and PTX groups (a, c) did not show pathologic alterations, and normal myocytes with clear nuclei were observed. Coagulative necrosis and inflammation were detected in the cardiac samples of the ATO-exposed mice (b). In the treatment groups (d–f), some pathologic alterations, such as coagulative necrosis and inflammation, were decreased in a dose-dependent manner. ATO: arsenic trioxide (equal 5 mg/kg); PTX: pentoxifylline.

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