Pentoxifylline Attenuates Arsenic Trioxide-Induced Cardiac Oxidative Damage in Mice

Table 2

Histopathological alterations of cardiac tissue in experimental groups.

Groups	Coagulative necrosis	Infiltration of inflammatory cells	Focal hemorrhage	Myocardial degeneration
Control
ATO (5 mg/kg)	^###	^###	^###	^###
PTX (100 mg/kg)
(25 mg/kg)
(50 mg/kg)
(100 mg/kg)

The results are expressed as , for each group. ^≠≠≠ vs. control group; and vs. ATO group. Statistical analysis used one-way ANOVA with Tukey’s test. The microscopic observations were scored as 0 (0%), 1 (1–25%), 2 (26–50%), 3 (51–75%), and 4 (76–100%) according to the percentage of histopathological changes. ATO: arsenic trioxide (equal 5 mg/kg); PTX: pentoxifylline.