Role of IL-37- and IL-37-Treated Dendritic Cells in Acute Coronary Syndrome

Figure 1

Ex vivo generation of tDCs and LPS desensitization. (a) DCs treated with IL-37 and TnI (oxLDL) display a tolerogenic phenotype. (b) LPS desensitization; IL-37-treated DCs from patients with ACS were phenotypically and functionally similar to IL-37-treated DCs from patients with NCA. TDCs: tolerogenic dendritic cells induced by troponin I (oxidized low-density lipoprotein) plus interleukin-37; LPS: lipopolysaccharide; IL-37: interleukin-37; TnI: troponin I; oxLDL: oxidized low-density lipoprotein; ACS: acute coronary syndrome; NCA: normal coronary artery.

(a)

(b)