Review Article
MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
Figure 2
The structure of MANF. (a) The model structure of MANF. The Saposin-like domain was marked as green, and the SAP-like domain was marked as orange. (b) MANF is constructed with 158 amino acids and eight helices. The Saposin-like domain is located near the N-terminus, and the SAP-like domain stands on the C-terminus. CKGC in human MANF situates in 127th to 130th amino acids, being responsible for the neuroprotective effect. Besides, RTDL at the very end of MANF effects as a tag to locate the protein in the endoplasmic reticulum.
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