MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders

Table 2

Potential drugs targeting MANF.

Drug	Subject	Target	Mechanism
Valproic acid	Rat	Brain	mRNA and protein expression of MANF increased
Piperine [89]	Mouse and PC12 cell	Brain	Antagonize ER stress by activating MANF expression
Paroxetine [90]	Primary astrocytes		Increasing mRNA expression of MANF
Metformin [91]	Human	Serum	Elevating serum MANF levels in PCOS women
Liraglutide [82]	Human	Serum	Upregulating MANF