Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms

Table 2

Registered coumarin clinical trials on the Clinicaltrials.gov database.

Title	Participants	Type of trial	Period	Outcomes
Effectiveness of a Multidisciplinary Medication Review with Follow-up for Patients Treated with Coumarin Anticoagulants in Primary Care; NCT03154489	204	Randomized	May 2017-May 2018	Effectiveness of medication review with follow-up. Principally studying INR control of these patients during 6 months
Efficacy and Safety of Coumarin and Troxerutin in the symptomatic Treatment of Chronic Venous Insufficiency; NCT01848210	829	Randomized	May 2013-September 2015	Mean Change (Reduction) from Baseline in Volume of Reference Le g at Week 16 Change in the partial volume of legs will be measured using a water plethysmometer.
Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared with Plasma in Patients with Acute Major Bleeding Caused by Anticoagulant Therapy; NCT00708435	216	Randomized	-	Percentage of participants achieving hemostatic efficacy of stopping an ongoing major bleed: at 1 and 4 hours after the end of infusion; Percentage of participants who had a rapid decrease of the international normalized ratio (INR) time frame: 30 minutes after the end of infusion
Anticoagulation in Liver Fibrosis; NCT00180674	12	Nonrandomized	August 2005-October 2006	-
An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared with Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure (BE1116_3003) NCT00803101	176	Randomized	February 2009-February 2013	Percentage of participants achieving hemostatic efficacy during surgery the start of infusion until the end of surgery; Percentage of participants who had a rapid decrease of the INR: 30 minutes after the end of infusion
Therapeutic Equivalence between Branded and Generic WARFArin Tablets in Brazil (WARFA) NCT02017197	100	Randomized	August 2014-August 2016	Difference between Delta INR at the fourth week of each period
Rivaroxaban Compared to Vitamin K Antagonist upon Development of Cardiovascular Calcification NCT02066662	192	Randomized	July 2013-active	Progression of coronary and aortic valve calcification (Agatston, volume & mass score as assessed by cardiac CT)