The Role of Unfolded Protein Response in Human Intervertebral Disc Degeneration: Perk and IRE1-<i>α</i> as Two Potential Therapeutic Targets

<div>UPR activation leads to the decreased biological activity of NPCs. The expression of UPR genes in NPCs treated by Tm was analyzed by real-time PCR (a) and western blot (b). (c) Cell proliferation was evaluated by the CCK-8 assay at days 1 to 7 after TM treatment. (d) The expression of Agg, Col2, and SOX9 following the exposure of NPCs to Tm was confirmed by western blot. <i>β</i>-Actin was used as an internal control. The representative results were from three independent experiments. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: The Role of Unfolded Protein Response in Human Intervertebral Disc Degeneration: Perk and IRE1-<i>α</i> as Two Potential Therapeutic Targets 

Oxidative Medicine and Cellular Longevity

The Role of Unfolded Protein Response in Human Intervertebral Disc Degeneration: Perk and IRE1-α as Two Potential Therapeutic Targets

Figure 2