DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway

Figure 10

DL0410 suppresses the TLR4/MyD88/TRAF6/NF-κB signaling pathway activation in LPS-stimulated BV2 microglia. Immunoblotting and densitometry analysis of TLR4, MyD88, TRAF6 (a), phospho-IκBα, and phospho-IKKα/β in BV2 cells (b). (c) Immunofluorescence staining for NF-κB p65 (green) and Hoechst (blue) in BV2 microglia. . (d, e) Immunoblotting analysis of NF-κB p65 (cytoplasm and nucleus) in LPS-induced BV2 microglia. . All values displayed are . ^# or ^## vs. control, and or vs. LPS-treated cells.

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