DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-<i>κ</i>B Pathway

<div>DL0410 decreased proinflammatory cytokine production in LPS-stimulated BV2 cells. The expression of NO (a), TNF-<i>α</i> (b), IL-1<i>β</i> (c), and IL-6 (d) was detected by ELISA. Intracellular ROS of BV2 microglia was detected by fluorescence intensity after incubation with H2DCFDA (e, f). The protein expression of COX2 (g) and iNOS (h) was measured and analyzed by Western blot. <span class="nowrap"><svg height="11.9544pt" id="M89" style="vertical-align:-3.42942pt" version="1.1" viewbox="-0.0498162 -8.52498 72.1595 11.9544" width="72.1595pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M372 352C427 368 507 407 507 502C507 548 486 592 451 616C420 638 376 650 301 650H44V622C124 616 128 610 128 527V123C128 40 122 34 36 28V0H257C336 0 402 12 453 40C512 72 548 124 548 191C548 291 471 335 372 350V352ZM213 362V558C213 591 216 602 226 608C235 614 258 618 282 618C377 618 415 558 415 490C415 406 369 362 260 362H213ZM213 328H258C380 328 450 283 450 181C450 76 377 35 296 34C231 34 213 53 213 125V328Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.761,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 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34 109 27V0H384Z"></path></g></svg> vs. the model group.</div>

Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-<i>κ</i>B Pathway 

Oxidative Medicine and Cellular Longevity

DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway

Figure 9