Cross-Talk between Oxidative Stress and m⁶A RNA Methylation in Cancer

Figure 1

The dual effects of oxidative stress in cancer progression. ROS play an anticancer role by promoting apoptosis, necrosis, and ferroptosis of cancer cells and enhancing the immune surveillance ability of immune cells. Conversely, ROS promoting cancer progression by inducing DNA damage and genomic alterations, activating cell proliferation-related pathway (NF-B, MAPKs, and PI3K/AKT/mTOR), accelerating EMT, and altering the tumor microenvironment for cancer invasion and metastasis.