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m6A enzyme | Cancer type | Role | Change in target RNA | Function of m6A enzyme | References |
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METTL3 | Acute myeloid leukemia | Oncogene | MYC↑, BCL2↑, PTEN↑ | Inhibiting cell differentiation and apoptosis, increasing cell growth | [244] |
Breast cancer | Oncogene | HBXIP↑ | Promoting cell proliferation, inhibiting apoptosis | [246, 277] |
Bladder cancer | Oncogene | miR-221/222↑, PTEN↓ | Promoting cell growth | [278] |
Oncogene | SETD7↓, KLF4↓ | Promoting cell proliferation and metastasis | [279] |
Colorectal cancer | Oncogene | SOX2↓ | Promoting tumorigenesis and cell metastasis | [280] |
Tumor suppressor | p-p38↓, p-ERK↓ | Inhibiting cell proliferation, migration, and invasion | [281] |
Glioblastoma | Oncogene | SRSFs↑ | Promoting tumor growth and progression | [282] |
Oncogene | ADAR1↑ | Promoting cancer progression | [283] |
Lung cancer | Oncogene | JUNB↑ | Increasing TGF-β-induced EMT | [284] |
Oncogene | BRD4↑ | Promoting oncogenic transformation and tumor growth | [285] |
Liver cancer | Oncogene | SOCS2↓ | Promoting cell proliferation, migration, and colony formation | [286] |
Oncogene | RDM1↓ | Increasing cell proliferation | [287] |
METTL3, METTL14 | Endometrial cancer | Tumor suppressor | PHLPP2↑, mTORC2↓ | Inhibiting cell proliferation | [288] |
Glioblastoma | Tumor suppressor | ADAM19↑, EPHA3↑, KLF4↑, CDKN2A↓, BRCA2↓, TP53I11↓ | Suppressing tumor genesis, growth, and self-renewal | [289] |
METTL14 | Acute myeloid leukemia | Oncogene | MYC↑, MYB↑ | Inhibiting cell differentiation, increasing cell proliferation | [290] |
Breast cancer | Oncogene | DROSHA↑ | Enhancing breast cancer stem-like cell stemness maintenance | [291] |
Colorectal cancer | Tumor suppressor | SOX4↓ | Inhibiting EMT | [292] |
Tumor suppressor | lncRNA XIST↓ | Suppressing proliferation and metastasis | [293] |
Pancreatic cancer | Oncogene | PERP↓ | Promoting tumor growth and metastasis | [294] |
WTAP | Liver cancer | Oncogene | ETS1↓ | Promoting cell proliferation and tumor growth | [295] |
FTO | Acute myeloid leukemia | Oncogene | MYC↑, CEBPA↑ | Promoting cell proliferation and viability, inhibiting cell-cycle arrest and apoptosis | [296] |
Oncogene | ASB2↓, RARA↓ | Enhancing cell transformation and leukemogenesis, inhibiting cell differentiation | [297] |
Liver cancer | Oncogene | ALDOA↑ | Promoting cell growth under hypoxia | [298] |
Ovarian cancer | Tumor suppressor | PDE1C↓, PDE4B↓ | Inhibiting the tumor self-renewal, suppressing tumorigenesis | [299] |
ALKBH5 | Acute myeloid leukemia | Oncogene | TACC3↑ | Promoting tumor development and self-renewal | [300] |
Lung cancer | Tumor suppressor | YAP↓ | Inhibiting tumor growth and metastasis | [301] |
Glioblastoma | Oncogene | FOXM1↑ | Promoting cell proliferation | [51] |
Pancreatic cancer | Tumor suppressor | PER1↑ | Reducing cell proliferation, migration, and invasion, suppressing tumor growth | [302] |
YTHDF1 | Lung cancer | Oncogene | CDK2↑, CDK4↑, cyclind1↑, Keap1↑ | Promoting cell proliferation and xenograft tumor formation | [215] |
Liver cancer | Oncogene | EGFR↑ | Promoting cell viability and metastasis | [303] |
Ovarian cancer | Oncogene | EIF3C↑ | Facilitating tumor genesis and metastasis | [304] |
YTHDF2 | Glioblastoma | Oncogene | MYC↑, VEGFA↑ | Maintaining glioblastoma stem cell stemness | [241] |
Liver cancer | Tumor suppressor | IL11↓, SERPINE2↓ | Reducing tumor inflammation and causing vascular abnormalities | [59] |
Prostate cancer | Oncogene | LHPP↓, NKX3-1↓ | Inducing tumor proliferation and migration | [305] |
YTHDF3 | Breast cancer | Oncogene | ST6GALNAC5↑, GJA1↑, EGFR↑ | Controlling the interaction of cancer and brain microenvironment, inducing brain metastasis | [306] |
Colorectal cancer | Oncogene | LncRNA GAS5↓ | Promoting cancer progression | [307] |
IGF2BP1 | Colorectal cancer | Oncogene | c-Myc↑ | Promoting tumorigenesis | [308] |
Ovarian, liver, and lung cancer | Oncogene | SRF↑, PDLIM7↑, FOXK1↑ | Promote cell growth and invasion | [309] |
IGF2BPs | Cervical and liver cancer | Oncogene | MYC↑ | Promoting tumorigenesis | [310] |
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