Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice

Figure 3

OA treatment prevented oxidative damage induced by DOX in cardiac tissue. (a, b) Myocardial 4-HNE and nitrotyrosine (). (c) GSH levels (). (c, d) Gpx and SOD activity (). (f–i) The mRNA levels of gp91phox, Nox4, p47phox, and p67phox (). (j) The protein expression of Nrf2 and downstream targets (). Differences between multiple groups were determined by one-way ANOVA followed by Tukey’s test. vs. control group, ^# vs. DOX group.

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