Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice

Figure 4

OA treatment attenuated inflammatory response and myocardial apoptosis in DOX-treated hearts. (a–d) Relative mRNA levels of inflammatory factors (). (e, f) The mRNA levels of MMP-2 and MMP-9 (). (g) The protein expression of p-IκBα and nuclear p65 (). (h) The protein expression of Bcl-2 (). (i) TUNEL staining and apoptotic rate (). (j, k) Caspase3/7 and PARP activities (). Differences between multiple groups were determined by one-way ANOVA followed by Tukey’s test. vs. control group, ^# vs. DOX group.

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