Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice

Figure 5

OA treatment exerted protection via Sirt1. (a, b) The Sirt1 protein expression and activity in vivo (). (c, d) The Sirt1 protein expression and activity in vitro (). (e, f) The production of ROS and superoxide (). (g) Nrf2 DNA binding activity (). (h, i) The mRNA levels of HO-1 and NQO1 (). (j) NF-κB binding activity (). (k) The mRNA level of TNF-α (). (l) Cell viability (). Differences between multiple groups were determined by one-way ANOVA followed by Tukey’s test. For (a–i), vs. matched control; for (j, k), vs. control group, ^# vs. DOX group, ^† vs. DOX+OA group.

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