Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice

Figure 6

Sirt1 depletion abolished the protection provided by OA. (a, b) The cardiac CK-MB and LDH in DOX-treated mice (). (c) EF in the indicated groups (). (d, e) Myocardial 4-HNE and nitrotyrosine (). (f) The protein expression of nuclear Nrf2 and NF-κB (). (g, h) Caspase3/7 and PARP activities (). Differences between multiple groups were determined by one-way ANOVA followed by Tukey’s test. vs. matched control.

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