Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice

Figure 7

OA treatment activated Sirt1 via cAMP/PKA signaling axis. (a, b) Relative NAD+ levels (). (c, d) Relative cAMP levels (). (e) Relative PKA activity in cells (). (f) Relative PKA activity in the hearts (). (g) Relative Sirt1 activity in cells (). (h) Cell viability of cells (). Differences between multiple groups were determined by one-way ANOVA followed by Tukey’s test. For (a–e), vs. control/PBS group, ^# vs. DOX group. For others, versus the matched group.

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