Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress

Figure 1

Dot1l was elevated in HSK progression. The corneal images were taken using a slit lamp (a) and calculated for opacity score (b) after HSV-1 infection 1, 3, and 7 days. The levels of Dot1l protein (c) were detected after HSV-1 infection 1, 3, and 7 days, and quantification of Dot1l expression (d) was determined in fold change relative to the 0 d group. SOD activity (e), MDA content (f), and H2O2 production (g) were also detected after HSV-1 infection 1, 3, and 7 days. Data were expressed as (). versus 0 d group. Experiments were repeated 3 times.

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