Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress

Figure 5

Inhibition of Dot1l alleviated oxidative stress induced by HSV-1 infection 12 hours in HCE cells. The expression of Dot1l, catalase, SOD1, and SOD2 were evaluated through western blot after transfection with siRNA against Dot1l (a–e). SOD activity (f), MDA content (g), ROS (h), and H2O2 production (i) were also detected at HSV-1 infection 12 hours in HCE cells, with siRNA against Dot1l. Data were expressed as (). versus control; ^# versus si-NC. Experiments were repeated 3 times.

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