Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress

Figure 6

Inhibition of Dot1l alleviated p38 MAPK activation and inflammation induced by HSV-1 infection 12 hours in HCE cells. The activation of p38 MAPK was evaluated through western blot after transfection with siRNA against Dot1l (a–d). The mRNA levels of proinflammatory factors, including IL-1β, MMP-1, MMP-2, IL-6, and MMP-9 (c–g), were also detected at HSV-1 infection 12 hours in HCE cells, with siRNA against Dot1l. Data were expressed as (). versus control; ^# versus si-NC. Experiments were repeated 3 times.

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