Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress

Figure 7

Inhibition of p38 MAPK expression alleviated oxidative stress and inflammation induced by HSV-1 infection 12 hours in HCE cells. The expression of catalase, SOD1, and SOD2 (a–d) were evaluated through western blot after pretreatment with SB203580 (1 μM) for 1 hour in HCE cells before HSV-1 infection. The mRNA levels of proinflammatory factors, including IL-1β, MMP-1, MMP-2, IL-6, and MMP-9 (e–i), were also detected after treatment with SB203580 (1 μM) for 1 hour in HCE cells before HSV-1 infection. Data were expressed as (). versus control; ^# versus DMSO. Experiments were repeated 3 times.

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